GLUCOSYLATED HYBRID TITANIUM DIOXIDE/POLYMER NANOMATERIALS OF CONTROLLED SIZE FOR ACTIVE TARGETING IN THE SONO-DYNAMIC THERAPY OF CANCER

Resumen

Sonodynamic therapy (SDT) is a minimally invasive and localized anticancer therapy based on the in situ generation of reactive oxygen species (ROS) by combining low-intensity ultrasound (US), oxygen, and a sonosensitizer and it minimizes systemic toxicity. We designed and synthesized a novel type of hybrid amorphous TiOamphiphilic poly(ethylene oxide)-poly(propylene oxide) block copolymers and their nanoprecipitation in water [1]. Nanoparticles can be produced with fine size control by changing the complex agin time and we demonstrated that they trigger cancer cell apoptosis in vitro [2]. Moreover, very recently, we demonstrated the ability of glucosylated hybrid nanoparticles to target tumors that overexpress glucose transporter-1 and improve their sono-dynamic anticancer activity in 2D and 3D tumor models in vitro and in vivo. Overall, our results highlight the promise of these novel platform in the sono-dynamic therapy of solid tumors. ₂/polymer nanomaterials that comprises the synthesis and aging of a Ti(IV)-acetone oxo-organo complex, its mixing with linear and branched

Acknowledgements. This research was funded by the Israel Science Foundation (ISF, Grant #327/19). Partial support of the Russell Berrie Nanotechnology Institute (Technion) is acknowledged.

References

1. Kushnirov Melnitzer V, Sosnik A, Novel hybrid titanium oxide/polymer amphiphilic nanomaterials with controlled size for drug encapsulation and delivery, Adv Func Mater 30, 1806146 (2020). https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201806146
2. Pariente A, Peled E, Zlotver I, Sosnik A, Hybrid amorphous TiOhttps://www.sciencedirect.com/science/article/pii/S2468519421001932 ₂/polymer nanomaterials trigger cancer cell apoptosis upon ultrasound irradiation, Mater Today Chem 22, 100613 (2021).